Magnesium Based Degradable Implants for Bone Defect Repair Applications

Medical Based Degradable Implants.

Industry: Medical-Orthopaedic, Pharmaceutical;

Applications:Bones, Fillers, Nails, Plates, Orthopedics, Other;

Market: The global Medical magnesium Implants market is projected to grow at CAGR of 9.8% during forecast period 2023 to 2029.

Watermarking IP design,

Electronic circuits

Repair of long segmental bone defects is challenging in orthopedic practice.
There are different metal and alloys used in orthopedic implants for the replacement or regeneration of damaged hard tissue/bones.
However, the use of permanent metallic implants causes stress shielding or mechanical mismatch or release of toxic metallic ions including chromium, etc. due to their wear & corrosion can happen.
Hence, there is a requirement to address said issues by introducing biodegradable and biocompatible material.

The present invention describes a magnesium alloy based medical implant adapted to define mesh cage for bone defect repairing with dip coating with nanocomposite of polymeric materials and Hydroxyapatite followed by electrospuncoating on the treated surfaces.
The coating of polymeric materials and Hydroxyapatiteis formed by dipping implant in solution of polymeric materials and hydroxyapatite twice for achieving the desirable coating and drying under vacuum at room temperature.
Fig. 1: Illustrates Fabrication of layer by layer nanostructured composite coated AZ31 mesh cage. A). SEM image and B) EDS of the coating.
Fig. 2: Illustrates AZ31 magnesium mesh cage for bone defects repair.
Fig. 3 : Illustrates Radiographic observation of the vivo rabbit animals after Day 1 and 2, 4, 6 and 8 weeks of A) Uncoated and B) LBL nanocomposite coated AZ31cage. After 4 weeks of post implantation coated cage was showed callus formation and subsequent duration (6-8 weeks) complete bone healing achieved.

Technical Perspective: Present method includes fabrication of magnesium-based implant that specifically is suitable for load bearing bone/skeletal bone defect repair applications.
Industrial Perspective: Nanocomposite coating in the form of thin layer & nanocomposite nanofibers on the implant that specifically suitable for controlling the degradation of the implant cage, thereby providing the adequate load bearing capacity until new bone formation in the defect region.

Prof. Mukesh Doble

Department of Biotechnology

TRL- 3

Proof of Concept ready & validated.

Technology Transfer