Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Multilayer Skin Tissue Models and Methods of Preparation Thereof
Technology Category/Market
Category – Applied Mechanics, Medical Devices
Applications- Biomedical optical spectroscopy, Optical biopsy, non-invasive disease diagnosis,
Industry- Healthcare, Biomedical, Optical diagnostic instruments, optical phantoms.
Market – The global market for biopsy devices was valued at approximately $2.1 B in 2021 and is expected to grow $2.2 B by 2022, increasing at a CAGR of 6.8% from 2022 – 2027.
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Problem Statement
- Optical biopsy measurements are mostly mediated by optical fiber probes placed near the target tissue to record signals under specific modalities of spectral acquisition and analysis.
- For verification, testing and calibration of such newly developed optical diagnostic tools, a special kind of stable, durable and reproducible object with well-controlled optical properties mimicking real tissue is required, which could be achieved with the help of optical phantoms.
- Further, molding techniques proposed in previous reports for fabricating such phantoms are time consuming.
- Precision as well as photo stability of the prepared phantoms are additional concerns. Therefore, there is a need for a low cost optical phantom formed of non-toxic ingredients.
Technology
- The present invention relates to tissue specific models for diffuse reflectance (DR) studies and in particular to fabrication of solid optical phantoms mimicking skin tissue.
- The disclosure provides for an optical phantom mimicking the diffuse reflectance spectral (DRS) response from human tissue such as skin forearm over a wide spectral range from 280-670 nm.
- The optical phantom (Refer Fig. 1) includes an epidermal layer (107), dermal layer (105), a base layer (103) and a hard tissue layer (101).
- The hard tissue layer (101) is obtained by coating a mixture of barium sulphate and xanthan gum over a glass surface.
- The base layer (103) is obtained by coating a bulk solution of gelatin and intralipid on the glass surface.
- The dermal layer (105) is obtained by coating the bulk solution additionally containing collagen and haemoglobin.
- The epidermal layer (107) is prepared from NADH (Nicotinamide Adenine Dinucleotide), FAD (Flavin Adenine Dinucleotide) and coffee solution added to the bulk solution.
Key Features/Value Proposition
- The tissue phantom device disclosed finds use in characterizing and validating the performance of fiber-based DRS probes.
- In various embodiments, the phantoms disclosed herein are configured to demonstrate close correlation of diffuse reflectance (DR) spectra with human forearm skin.
- The fabricated phantoms are intended to have high potential in the design and validation of several optical spectral analysis-based instrument systems, leading to non-invasive optical biopsy procedures in the healthcare industry.
- Furthermore, as the phantoms are configured to be made tissue specific, the spectral database resulting from the investigations on these phantoms can help in the statistical analysis concerned with in-vivo measurements on specific tissues.
Questions about this Technology?
Contact for Licensing
smipm-icsr@icsrpis.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Sujatha. N
Department of Applied Mechanics
Intellectual Property
- IITM IDF Ref. 1631
- IN 201841007589
- PCT/IN2019/050135
Technology Readiness Level
TRL – 4
Experimentally validated in lab.