• Doping of optically luminescent nanomaterials creates contrast agents for hybrid imaging system that aids visualization of drug development process
• Europium dopant in various hosts have been extensively studied as a scintillating material for X-ray detectors and also as nano-contrast agent for optical and MRI that exhibits sharp emission peak, low toxicity, low photo bleaching and it is chemically stable
• The existing technologies involves lengthy process, issues with precursor mixing and dispersion, micro emulsion stability, yield etc

• The present invention provides a nanoparticle contrast and method thereof comprising Eu3+:TaOx wherein  Europium (Eu) is doped in Tantalum oxide (TaOx);  Europium precursor is Europium (III) chloride (EuCl3)  and Tantalum precursor is Tantalum (V) ethoxide
• Europium is doped in Tantalum oxide having dopant percentage ranging from 2-10%.
• The nanoparticles are quasi spherical in structure and having size ranging from 5 to 25 nm

Method involves :

• Preparing an oil in water solution((2 mL of Igepal, 600 μL ethanol (99.9%) and 600 μL NaOH (75 mM))
• Formation of Micro-Emulsion Solution (20 mL of cyclohexane and incubation for 10 mins)
• Introducing Tantalum Precursor and formation of Eu3+:TaOx
• Breaking the Micro-Emulsion Layer and Washing with acetone and ethanol
• Drying the Nanoparticles(100°C for 24 hours) to yield Europium doped TaOx nanoparticles