Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Technology Category/ Market
Technology: Diagnostic Probe/Sensors
Industry: Pathology based Instruments, Pharmaceutical; Applications: Instrument for cancer detection;
Market: The global cancer diagnostic market was valued at $135.16B in 2022, projected to reach $258.54B by 2030, growing at a CAGR of 8.4% from 2022 to 2030.
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Problem Statement
- In the prior arts literatures, it is known that hydrozen sulfide (H2S) detection & quantifications have relied mainly on its reactivity as a nucleophile or as a reductant.
- Metal sulphide formation with concomitant formation of an emissive compound from a pre-fluorophore is another approach.
- Though fluorescence-based methods are reliable, emission of many of these probes get affected in presence of proteins such as albumin, which could lead to errors during quantifications & various solutions discussed which results unsatisfactory in terms of different parameter detection & quantification
- Hence, there is a requirement of an efficient solution to address the above issues.
Technology
- Patent subject matter talks about diagnostic and therapeutic applications of 1H-pyrrol-3(2H)-one derivatives.
- The 1H-pyrrol-3(2H)-one core is suitably derivatized to act as a chemical probe for selective detection & quantification of the gasotransmitters such as hydrozen sulfide.
- The subject invention provides multimodal detection through characteristic “turn-on” fluorescent output and Raman signals possible by using proper response groups.
- More specifically, the use of compounds of the general structure I, which comes under general structure IV, as chemical probes for the selective detection and quantification of an analyte such as H2S in various samples such as blood plasma. And the concentration of said probe used, can be 10 µM to 200 µM in blood plasma.
Key Features/ Value Proposition
Technical Perspective:
Claimed Patent provides a diagnostic apparatus, for detection & quantification of H2S, which ensures high level of selectivity & sensitivity.
Industrial Perspective:
The proposed probe/apparatus ensures high accuracy, fast response with low nanomolar detection limit, high stability for diagnostic & therapeutic potential, applicable especially in the area of cancer, & fast response.
Questions about this Technology?
Contact for Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Muraleedharan K M
Department of Chemistry
Intellectual Property
- IITM IDF Ref. 2353
- IN Patent No: 202241034179
Technology Readiness Level
TRL- 4
Proof of Concept ready & validated