Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Technology Category/ Market
Category – Advanced materials/ Drugs & Pharmaceutical Engineering
Applications -Drug delivery, Tissue engineering, biosensor, biomedical applications
Industry – Healthcare, Nano materials
Market -The Global Nano-polymers Market size is USD 9.97 billion in 2023 and is estimated to grow to USD 31.48 billion by 2030. This market is witnessing a healthy CAGR of 17.85% from 2024 – 2030.
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Problem Statement
- Polymeric nanomaterials, synthesized through ring-opening copolymerization (ROCOP) reactions using metal catalysts, have gained widespread use in biomedical applications.
- However, the conventional metal catalysts employed in this process pose significant safety and environmental concerns such as Accumulation of Metal Contaminants
Technology
The present invention discloses a method for developing metal-free poly(tBGE–alt-PA) copolymer based nano- drug carriers for combinatorial cancer therapeutics
Synthesising poly(tBGE-alt-PA) copolymer via. ROCOP reaction using B(C2H5)3/ PPNCl–based Lewis Pair (LP) as catalyst in order to obtain a metal-free polyester
Developing nano-drug carrier composed of poly(tBGE-alt-PA) copolymer loaded with doxorubicin (DOX), curcumin (CUR) and their combination (DOX/CUR)
Converting DOX-HCL into its free base form before loading and preparing blank poly(tBGE-alt-PA), poly(tBGE-alt-PA)-DOX, poly(tBGE-alt-11 PA)-CUR, and poly(tBGE-alt- PA)-DOX/CUR NPs by dialysis method (72 hours)
Collecting each NP solution and kept for freeze drying up to 48 hours in a lyophilizer to get obtain the powdered form.
- TEM images showed the spherical shape for all drug loaded NPs.
- The internal morphology of NPs displayed core-shell structure, further polydispersity was observed in NP’s size
The percentage of apoptotic cells in DOX, CUR, poly(tBGE-alt-PA)-DOX, 33 poly(tBGE-alt-PA)-CUR, and poly(tBGE-alt-PA)-DOX/CUR NPs treated MIA 34 PaCa-2 cells were found to be 6.80, 6.60, 13.05, 29.50, and 85.85 % respectively.
Key Features/ Value Proposition
Technical Perspective:
- Poly(tBGE–alt-PA) copolymer is synthesised initially via. ROCOP reaction using B(C2H5)3/PPNCl–based Lewis Pair (LP) as catalyst in order to obtain a metal-free polyester.
- Said nano-drug carriers composed of poly(tBGE-15 alt-PA) copolymer proposed displays high encapsulation and drug loading efficiency and exhibited sustained drug release behaviour with anomalous transport at defined physiological environment.
User Perspective:
- It provides an provide for an improved metal-free synthesis of Polyesters for use in biomedical applications
- The co-delivery mechanism of both drugs doxorubicin (DOX), curcumin (CUR) and their combination (DOX/CUR) with drug loaded nanoparticles displays maximum anti-cancerous therapeutic effect on several cancer lines of different origins.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. RAMA S VERMA
Department of Biotechnology
Prof. DEBASHIS CHAKRABORTY
Department of Chemistry
Intellectual Property
- IITM IDF Ref. 1683
- IN475521-Granted
Technology Readiness Level
TRL-4
Technology Validated in Lab