Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Method for Blood Plasma Separation based on Acoustocapillary and Asymmetric Capillary Flow
Categories for this Invention
Technology: Microfluidic Device;
Industry: Pharmaceutical, Medical device;
Application: Medical Test Equipment;
Market: The global microfluidic device market is projected to reach $158.1B by 2031, at a CAGR of 22.4% during (2023-2031)
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Problem Statement
- Generally, the primary output from several full field deformation measurement techniques is digital image. Further correlation is the displacement vector at a dense grid of points covering the area of interest, wherein one is interested in strains which is computed from spatial derivatives of displacement.
- However, computed displacement data inherently contain noise & difficult to obtain strains.
- Hence, there is a need to address the issues.
Technology
- Present invention describes a microfluidic device for separation of plasma from blood cells.
- Said Patent further discloses a method for blood plasma separation using microfluidic device based on acoustocapillary and asymmetric capillary flow.
- Said microfluidic device comprises a polydimethylsiloxane (PDMS) microchannel layer bonded with a PDMS coated glass thereby making the glass walls hydrophilic slide and the bottom wall of the microchannel is hydrophobic.
The acoustic radiation force on the blood cells act towards the center of the channel or node makes blood cells to concentrate at the center of the channel & cell-free plasma at the walls or anti-node and the acoustic waves propagate in the width wise direction which makes the cells to move in the y direction.
- The method for blood plasma separation using microfluidic device is illustrated in below smart chart & figures:
Key Features / Value Proposition
Technical Perspective & Industrial Perspective:
- Present invention facilitates simple diagnostic process cum handy device including features like improvised quality, reproducibility & reliability of the assay results. (Refer Fig.1 illustrates acousto-capillary based blood plasma separation process.)
- Provides a capillary driven blood plasma separation device designed both in horizontal configuration & vertical configuration.
- Enabled realization of a lab on chip diagnostic platform.
- The cell-free plasma at the walls can be separated from the blood cells using a trifurcated channel configuration & separated plasma can be collected at the outlets for further analysis or detection.
- A suction chamber can also be used to control fluid flow along with the capillary flow.
- Cost-effective & time-consuming process.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Ashis Kumar Sen
Department of Mechanical Engineering
Intellectual Property
IITM IDF Ref. 1385
Patent No:410407
Technology Readiness Level
TRL-3
Proof of concept tested in Lab;