Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Functionally Gradient 3-layered Graphene Foam-polymer Scaffold for Periodontal Regeneration
Categories for this Invention
Technology: Graphene foam – polymer scaffold
Category: Biotechnology & Genetic Engineering
Industry: Bio Medical Engineering
Application: Periodontal regeneration,bone and bone related tissue regeneration
Market: The global market size was grown rapidly in recent years. It will grow from $282.19 billion in 2023 to $320.38 billion in 2024 at a compound annual growth rate (CAGR) of 13.5%.
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Problem Statement
- Periodontitis is an inflammation caused by biofilms, causing tooth loss and edentulism.
- Traditional treatments involve guided tissue regeneration using periodontal membranes.
- Graphene, with its large surface area, high thermal and electrical conductivity, and superior mechanical properties, has been used in engineering and biomedical fields.
- Recent developments in 3D graphene foams (GFs) have been developed to avoid agglomeration and facilitate uniform distributions, making them ideal for scaffold preparation in tissue engineering and regenerative medicine.
- However, there is a gap in understanding 3-D organization in multicellular tissue formation and functional restoration on scaffolds.
Technology
- “Functionally Gradient 3-Layer Graphene Foam Polymer Scaffold for Periodontal Regeneration“
- Created with three distinct layers.
- Layers prepared with distinct reinforcement, morphology, porosity, and mechanical strength.
- Combines spin coating and vacuum drying sequentially.
Key Features / Value Proposition
Graphene Foam Creation:
- Three distinct layers with unique reinforcement, morphology, porosity, and mechanical strength.
Graphene Foam Surface Coating:
- Diluted PCL solution (4% w/v) for structural stability.
- Dip-coated and vacuum dried.
Dip-Coated GF Structural Similarity:
- Shows structural similarity to middle periodontal ligaments.
- Provides directional cell migration cues.
Cementum Side Preparation:
- Reinforcement with highly concentrated PCL.
- Spin-coating for reinforcement.
“PVA Coating Process”:
- Water-soluble polymer coated.
- Spin-coating up to desired middle layer thickness.
The last layer is prepared with PCL (15%w/v)-HA solution:
- to mimic the bone layer.
Adjusting Layer Thickness and Porosity:
- Manipulating spin coating duration.
- Adjusting layer porosity with polymer concentration and vacuum drying parameters.
Reinforcing Polymers for Tissue Regeneration:
- Useful for other tissue regeneration applications.
Periodontitis Treatment Overview:
- Regeneration of cementum, periodontal ligament, bone.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Tuhin Subra Santra
Department of Engineering Design
Intellectual Property
IITM IDF Ref.2055
Patent No: IN 545761
Technology Readiness Level
TRL- 3
Experimental Proof of concept