Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras

Technology Category/ Market

Category – Advanced materials/ Drugs & Pharmaceutical Engineering

Applications -Drug delivery, Tissue engineering, biosensor, biomedical applications

Industry – Healthcare, Nano materials  

Market -The Global Nano-polymers Market size is USD 9.97 billion in 2023 and is estimated to grow to USD 31.48 billion by 2030. This market is witnessing a healthy CAGR of 17.85% from 2024 – 2030.

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Problem Statement

  • Polymeric nanomaterials, synthesized through ring-opening copolymerization (ROCOP) reactions using metal catalysts, have gained widespread use in biomedical applications.
  • However, the conventional metal catalysts employed in this process pose significant safety and environmental concerns such as Accumulation of Metal Contaminants


  • The present invention discloses a method for developing metal-free poly(tBGEalt-PA) copolymer based nano- drug carriers for combinatorial cancer therapeutics

  • Synthesising poly(tBGE-alt-PA) copolymer via. ROCOP reaction using  B(C2H5)3/ PPNCl–based Lewis Pair (LP) as catalyst in order to obtain a metal-free polyester

  • Developing nano-drug carrier composed of poly(tBGE-alt-PA) copolymer loaded with doxorubicin (DOX), curcumin (CUR) and their combination (DOX/CUR)

  • Converting DOX-HCL into its free base form before loading and preparing blank poly(tBGE-alt-PA), poly(tBGE-alt-PA)-DOX, poly(tBGE-alt-11 PA)-CUR, and poly(tBGE-alt- PA)-DOX/CUR NPs by dialysis method (72 hours)

  • Collecting each NP solution and kept for freeze drying up to 48 hours in a lyophilizer to get obtain the powdered form.

  • TEM images showed the spherical shape for all drug loaded NPs.
  • The internal morphology of NPs displayed core-shell structure, further polydispersity was observed in NP’s size
  • The percentage of apoptotic cells in DOX, CUR, poly(tBGE-alt-PA)-DOX, 33 poly(tBGE-alt-PA)-CUR, and poly(tBGE-alt-PA)-DOX/CUR NPs treated MIA 34 PaCa-2 cells were found to be 6.80, 6.60, 13.05, 29.50, and 85.85 % respectively.

Key Features/ Value Proposition

Technical Perspective:

  • Poly(tBGEalt-PA) copolymer is synthesised initially via. ROCOP reaction using B(C2H5)3/PPNCl–based Lewis Pair (LP) as catalyst in order to obtain a metal-free polyester.
  • Said nano-drug carriers composed of poly(tBGE-15 alt-PA) copolymer proposed displays high encapsulation and drug loading efficiency and exhibited sustained drug release behaviour with anomalous transport  at defined physiological environment.

User Perspective:

  • It provides an provide for an improved metal-free synthesis of Polyesters for use in biomedical applications
  • The co-delivery mechanism of both drugs doxorubicin (DOX), curcumin (CUR) and their combination (DOX/CUR) with drug loaded nanoparticles displays maximum anti-cancerous therapeutic effect on several cancer lines of different origins.

Questions about this Technology?

Contact For Licensing

Research Lab


Department of Biotechnology


Department of Chemistry

Intellectual Property

  • IITM IDF Ref. 1683
  • IN475521-Granted

Technology Readiness Level


Technology Validated in Lab

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