Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
A Method of Preparation of Scaffold with Varying Pore Size and Porosity as Bone Replacements
Categories for this Invention
Technology: Preparation of Scaffold with Varying Pore size
Category: Advanced Materials/Additive manufacturing
Industry: Casting/Biomedical industry
Application: Fabricate bone like structures Market: The global market size of bone substitutes is estimated to be $124-154 billion by 2023 with the CAGR of 6.3% from the year 2017.
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Problem Statement
- The demand for synthetic bone substitutes is increasing due to aging, sports, and accidents.
- Resorbable bone replacements have limitations due to their inherent strength limitations.
- Research focuses on efficient and economical bone implant fabrication, aiming to make implants biofriendly and economical.
- Techniques like gas forming, particulate leaching, phase separation, and freeze casting are used.
- Porous implants are found to be more cost-effective and body-friendly, and the biomedical industries are seeking a reliable and cost-effective method for manufacturing porous scaffolds.
- The main challenge in particular is making the implant as porous as in a bone structure so that the implant thus made is biofriendly and economical.
Technology
- A method for the preparation of a scaffold of varying pore size and porosity as bone replacement comprising of
- Preparing a solid holding of primary material with
- The bio-adaptable material and
- A freezing vehicle;
- Loading of the primary material in a mould wherein
- A base is provided with thermal conductive materials K1 and K2 of varying thermal conductivity;
- Freeze casting of the primary material, followed by deep freezing;
- Sublimating the demoulded material for 24 hours at 25 °C to form scaffold sintering the scaffold in a muffle furnace with variable heating and cooling rate of 5-10 °C/min; and
- wherein the porosity of the scaffold differs at the centre to the periphery.
Key Features / Value Proposition
- Porous scaffolds with variable porosity and pore size at desired location. using
- Freeze casting, mimicking bone-like structures.
- Bio-adaptable material is selected from metals, ceramics and polymers.
- Metal is one of titanium, cobalt,chromium alloy, or biograde stainless steel
- Ceramic is one of tricalcium phosphate, bioglass or alumina
- Polymer is one of Polylactic acid (PLA),
Thermal conductivity
- Material K1 is preferably Aluminium.
- Material K2 is preferably kapton tape
- K1>K2.
- Pore size of the scaffold
- Range of 1μm to 2.5 μm.
- At the Center is in the range of 1.75 μm to 2.5 μm.
- At the Periphery is in the range of 1μm- 1.5 μm
Primary material
- solid holding 30-40 % of the total slurry
- Mixing of the primary material is at a temperature of 55 °C – 60 °C for 2.5 to 3 hours
- Freezing vehicle is camphene.
- freeze casting of the material is 5 at -5 °C to -15 °C for 20-30 minutes.
- deep freezing of the material is at -15 °C to -25 °C for 20-30 minutes.
Tissue regeneration,
- Create a porous and strong scaffold for osseous tissue regeneration,
- Allowing new cells to grow and penetrate surrounding tissues.
- Promotes rapid bone growth
- Prevents crushing during integration and healing.
- Manufacturing orthopedic implants at low cost.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Soundarapandian S
Department of Mechanical Engineering.
Intellectual Property
IITM IDF Ref. 1867
Patent No: IN 505180
Technology Readiness Level
TRL-4
Experimentally validated in Lab