Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras

A Nanoparticle Contrast Comprising Eu3+:taox and Process of Preparation thereof

Technology Category/Market

Category – Advanced Materials

Applications –Medical Imaging Techniques, Drug delivery systems , sensors, nanotechnology

Industry – Biomedical Engineering

Market -The global advanced materials market size was estimated at USD 61.35 billion in 2022 and it is expected to hit around USD 112.7 billion by 2032, poised to grow at a CAGR of 6.27% from 2023 to 2032


Problem Statement

  • Doping of optically luminescent nanomaterials creates contrast agents for hybrid imaging system that aids visualization of drug development process
  • Europium dopant in various hosts have been extensively studied as a scintillating material for X-ray detectors and also as nano-contrast agent for optical and MRI that exhibits sharp emission peak, low toxicity, low photo bleaching and it is chemically stable
  • The existing technologies involves lengthy process, issues with precursor mixing and dispersion, micro emulsion stability, yield etc


  • The present invention provides a nanoparticle contrast and method thereof comprising Eu3+:TaOx wherein  Europium (Eu) is doped in Tantalum oxide (TaOx);  Europium precursor is Europium (III) chloride (EuCl3)  and Tantalum precursor is Tantalum (V) ethoxide
  • Europium is doped in Tantalum oxide having dopant percentage ranging from 2-10%.
  • The nanoparticles are quasi spherical in structure and having size ranging from 5 to 25 nm

Method involves :

  • Preparing an oil in water solution((2 mL of Igepal, 600 μL ethanol (99.9%) and 600 μL NaOH (75 mM))
  • Formation of Micro-Emulsion Solution (20 mL of cyclohexane and incubation for 10 mins)
  • Introducing Tantalum Precursor and formation of Eu3+:TaOx
  • Breaking the Micro-Emulsion Layer and Washing with acetone and ethanol
  • Drying the Nanoparticles(100°C for 24 hours) to yield Europium doped TaOx nanoparticles

Key Features/Value Proposition

Technical Perspective:

  • Novel and simple synthesis for preparation of Eu3+:TaOx nanoparticle
  • Combination of highly efficient  europium and Tantalum nanoparticles for the hybrid imaging system.

User Perspective:

  • Proposes use of Eu3+:TaOx nanoparticle as nanoprobes for simultaneous X-ray, CT, XEOL imaging etc.
  • Tantalum (TaOx) nanoparticle is a promising CT contrast agent with low cost, availability of material, highly biocompatible and easy to synthesize
Questions about this Technology?

Contact for Licensing

Research Lab

Prof. Ganapathy Krishnamurthi

Department of Engineering design

Intellectual Property

  • IITM IDF Ref. 2233
  • IN202141062007

Technology Readiness Level


Technology Validated in Lab

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