Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras

An Improved Bioceramic Mineral Releasing Bioactive Tetracalcium Phosphate Cements and Method of Producing the same from Egg Shells Waste

Technology Category/Market

Category: Material Science

Industry: Pharmaceutical Industry;

Applications: Medicine and bioactive minerals,  treatment of deep caries in dental applications.

Market: The global market of bioactive materials  was around USD 2.0B in 2020; expected to  increase at a CAGR of 14.0% during the time  period of 2021-2028.

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Problem Statement

  • Deep Dental Caries management is a big problem in dental clinics as dietary carbohydrates ferment by caries leads pH drop  below 5.5, causing demineralization of enamel &  potential damage to underlying tooth structure
  • Conventional remedies for oral cavity are conventional grinding hand pieces, lasers and air-blasting apparatus, but these  remedies are not successful.
  • Hence, there is a requirement to address said issues by introducing improved Bioceramic mineral using the egg shell waste.

Technology

Patent disclosure explains an improved method for  producing a bioceramic mineral releasing  bioactive tetracalcium phosphate cements.

The method comprises the steps of:

  • Mixing calcium carbonate of egg shells waste with  dicalcium phosphate anhydrous (DCPA)
  • Heating at 1500ºC for 6-12 hours in order to  synthesize Tetracalcium phosphate

  • Mixing synthesized Tetracalcium Phosphate with  the liquid component of the cement containing  1M disodium hydrogen phosphate (Na2HP04)  containing 10% citric acid using dental cement  spatula in L/P ratio of 0.5mI/g

  • Packing the mixture in a mold and allowing the mixture  to harden for obtaining improved Bioceramic mineral  releasing Bioactive Tetracalcium Phosphate Cements.

  • The said method further induce secondary dentin formation due to sustained calcium hydroxide release of the Bioceramic material.
  • The Tetracalcium phosphate cement is modified by addition of other calcium phosphates having Ca/P ratio lower than 2.

Key Features/Value Proposition

  • Bioceramic material is used as a bone  reconstructive material including bone  graft and bone substitute.
  • Bioceramic material releases calcium  hydroxide Ca(OH)2 over extended periods  of 48 days to maintain mechanical integrity.
  • It is used as multipurpose Bioceramic self-setting cement for dental caries affected  tooth as antibacterial dental cement, enamel  and dental remineralization, root canal filler,  dental liners and bases, and luting material.
  • Hydrolysis of the Tetracalcium Phosphate to  HA and Ca(OH)z occurs slowly under  physiological conditions due to the release of  calcium hydroxide raising the pH and the  mechanical strength of Bioceramic material  is not far from clinical requirements.
Questions about this Technology?

Contact for Licensing

Research Lab

Prof. Sampath Kumar T S

Department of Metallurgical & Materials Engineering

Intellectual Property

  • IITM IDF Number: 1193
  • IP Patent Number: 419821 (Granted)

Technology Readiness Level

TRL- 3/4

Proof of concept ready Stage

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