• The invention relates to a process for the preparation of Quinolone and Naphthyridone derivatives (Formula VII) using Baylis-Hillman adducts and amines.

The Invention Discloses:

• The structural variations and permissible substituents (R1, R2, R3, R4, R5, and A) within the quinolone and naphthyridone molecules, encompassing a wide array of potential modifications.
• The process for synthesizing these derivatives, starting from a Baylis-Hillman adduct (formula VIII) and an amine compound (formula IX).
• It involves a base-catalyzed reaction to yield 4-hydroxy-1,2,3,4-tetrahydroquinoline or 4-hydroxy-1,2,3,4-tetrahydro-1,8-naphthyridine derivative (formula X), followed by oxidation to produce the quinolone or naphthyridone derivative (formula VII).
• It cover specific aspects of the synthesis process, such as:
• the intermediate obtained after step a) doesn’t require chromatographic purification before proceeding to the next step.
• specify the solvents suitable for steps a) and b) respectively, providing a broad range of temperature, the reaction time.
• enumerates various bases suitable for the reaction in step a).
• lists oxidizing agents that can be used in step b), offering a variety of choices.
• reiterates that the amines used in step a) must possess the same R1 groups as defined in the previous claims.