Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Cancer Chemopreventive Formulation of PM 002 / Broad Spectrum Anticancer Formulation Of PM 002
Categories for this Invention
Drug & Pharmaceutical Engineering
Industry: Pharma & Herbal Medicine Industry
Application: Chemotherapy, Herbal Medicine Development, Cancer Treatment
Market: The global cancer therapeutics market size is expected to be worth around US$ 393.61 Billion by 2032 from at US$ 164 Billion in 2022, growing at 9.20% CAGR during the forecast period 2023 to 2032.
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Problem Statement
- Cancer chemotherapy, which involves the use of drugs to inhibit or kill cancer cells utilizes natural products as anticancer drugs source.
- While several plant compounds classes are explored for their chemotherapeutic potential, aromatic plant extract is not extensively studied.
- With the demand for safer cancer treatments on the rise, there is a crucial need to explore new sources of therapeutic compounds.
- A readily available natural resource with diverse biological activity: Pamburus missionis is a promising option. So, this invention is disclosed.
Technology
The instant invention discloses a method of preparation of a chemotherapeutic formulation from Pamburus missionis (Wight) Swingle extract, comprising:
- Passing steam at 75-95°C over fresh leaves of Pamburus missionis (Wight) Swingle for 3-10 hours to obtain a distillate;
- Recovering the extract from the distillate using solvent extraction method;
- Mixing with physiologically acceptable carrier to obtain the formulation.
Cytotoxic activity of Pamburus missionis essential oil/extract of FIG. 1A human adenocarcinoma cell lines; FIG. 1B on human leukemia cell lines.
Key Features / Value Proposition
- Effective treatment option for solid & leukemic cancers. Natural & plant-based formulation, potentially appealing to those seeking alternative or complementary therapies. Minimal toxicity to non-cancerous cells, reducing side effects.
- Opportunity for pharmaceutical companies to develop and market a novel cancer treatment derived from natural sources.
- Utilization of sustainable and eco-friendly extraction methods aligning with consumer preferences for green products.
- Extraction method yields a potent blend of sesquiterpenes, oxygenated sesquiterpenes, monoterpenes, ketones, and aldehydes, known for their anticancer properties.
- Formulation can be tailored into various pharma formats for ease of administration.
- Demonstrated cytotoxic activity against cancer cells at low dosages, indicating high efficacy.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Rama S Verma
Department of Biotechnology
Intellectual Property
IITM IDF No: 1200
IN IP No: 414895(Granted)
Technology Readiness Level
TRL – 4
Technology validated in lab.