Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
A Formulation Comprising Nano-scale Anti-cancer Compound
Technology Category/Market
Technology: A formulation comprising nano-scale anti-cancer compound
Category: Drugs & Pharmaceutical Engineering
Industry: Pharmaceutical industry
Application: Anticancer
Market: The global market size was valued at USD 1482.0 billion in 2022 and is expected to grow at a CAGR of 6.12% from 2023 to 2030.
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Problem Statement
- Nanotechnology’s versatility in cancer medicine includes easy permeation through blood vessels, improved therapeutic efficacy, prolonged half-life, controlled release, improved bioavailability, enhanced site specificity, reduced dosage concentration, and less or no toxic side effects.
- Studies show the therapeutic potential of polyphenolic components from spices and their oils, with potent cytotoxic and antimicrobial activity.
- A nano-scaled formulation of Indian celery oil using a simple microemulsion technique shows potent anticancer activity in human cancer cell lines.
- The ease of preparation, easy availability, bio-based approach, and utilization of nanotechnology could lead to a major breakthrough in cancer treatment at low-dosage concentrations with limited or no side effects.
Technology
Method of preparation of a nano-scaled anti-cancer compound:
- Indian spice oil (Celery): Non-ionic surfactant (Tween 20) mixture (1:6).
- Water added dropwise to the mixture at a constant stirring rate of 500 rpm
- Technique involved is conventional titration technique at laboratory conditions
- Clear and transparent nano-scaled emulsion formed spontaneously through self-assembly
- Demonstrated potent cytotoxicity against colon cancer cell line (HCT-116 wild type) through apoptosis mechanism
- Optimized formulation A6 chosen based on clarity,stability,small droplets in nano range ,low viscosity ,ease to form spontaneously , cost effectiveness and potent cytotoxic activity against colon cancer cell
Key Features/Value Proposition
Seed Oil Use
- Formulation uses seeds from various Apium species. • Rich in antioxidants, flavonoids, essential fatty acids.
- May have anti-cancer properties by inhibiting tumor growth and promoting cell apoptosis.
Nano-Scale Emulsion Stabilization with Non-Ionic Surfactants
- Tween 20 and Tween 80 stabilize nano-scale emulsion.
- Solubilize hydrophobic Apium seed oils in water.
- Ensures effective delivery of bioactive compounds.
Nano-Scale Emulsion Formation
- Enhances bioavailability and absorption of active compounds.
- Larger surface area facilitates efficient interaction with cancer cells.
- Improves formulation effectiveness.
Simple Preparation Method for Emulsion
- Mixing Apium seed oil with non-ionic surfactant.
- Dropwise adding organic phase to water.
- Stirring mixture at 400-600 rpm with magnetic stirrer.
- Allows spontaneous nano-scale emulsion formation.
Final Emulsion Transparency
- Indicates stable dispersion of oil droplets at nano-level.
- Suggests small particle size, ideal for stable, bioactive delivery system.
Seed Oil Concentration in Formulation
- Uses Apium spp. seed oil at 4-6% v/v.
- Optimized for therapeutic effect and nano-emulsion stability.
- Organic Phase Composition Flexibility
- Allows mixing of Apium seed oil and non-ionic surfactant.
- Optimizes formulation for anti-cancer activity.
- Emulsion selection based on transparency.
Applications of the Nano-Scale Anti-Cancer Compound Formulation:
- Topical Application for Skin Cancer:
- Systemic Cancer Treatment:
- Enhanced Bioavailability for Cancer Therapy:
- Drug Delivery Platform:
- Combination Therapy:
- Cancer Prevention:
- Cosmetic Anti-Cancer Applications
Questions about this Technology?
Contact for Licensing
Research Lab
Prof. Nagarajan R,
Department of Chemical Engineering
Intellectual Property
IITM IDF Ref. 1424
Patent No: IN 493315
Technology Readiness Level
TRL- 3
Experimental proof of concept