Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Conjugated Beta-glucan Nanoparticles for Targeted Delivery Applications
Categories for this Invention
Category – Nanobiotechnology
Applications – Pharmaceutical Drug Delivery, Nutraceuticals
Industry – Pharmaceuticals and Biotechnology
Market- Global Beta-Glucan market was valued at US$ 535.3 million in 2023 and is projected to reach US$ 860.4 million by 2030, at a CAGR of 6.9%.
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Problem Statement
- Need for an enhanced method to prepare β-1,3 glucan (curdlan) nanoparticles efficiently.
- Requirement for improved conjugated beta-glucan nanoparticles for targeted delivery of bioactive elements, pesticides/fertilizers, and food supplements.
- Identifying the necessity for addressing technological gaps in the production and application of beta-glucan nanoparticles for diverse therapeutic and agricultural purposes.
Technology
- The method involves dissolving Curdlan in formic acid, then adding it to a water/ethanol solution with Pluronic F-127 to prepare Curdlan nanoparticles. These nanoparticles are precipitated, washed with ethanol, and lyophilized.
- Cyclodextrin is conjugated onto the Curdlan nanoparticles using epichlorohydrin. This conjugation allows for the loading of drugs such as Rifampicin and Levofloxacin onto the nanoparticles, forming inclusion complexes.
- The drug-loaded nanoparticles exhibit sustained release profiles, with higher loading efficiency and controlled release compared to direct drug loading onto Curdlan nanoparticles. This technology offers potential applications in targeted drug delivery for various therapeutic and agricultural purposes.
Key Features / Value Proposition
Advanced Drug Delivery:
- Leveraging conjugated beta-glucan nanoparticles for targeted delivery offers enhanced efficacy and controlled release, addressing critical needs in pharmaceuticals.
Versatile Applications:
- From bioactive elements delivery to agricultural solutions like pesticides/fertilizers, the technology caters to diverse sectors, ensuring broad market penetration and adaptability.
Improved Efficiency:
- Higher loading efficiency and sustained release profiles of drug-loaded nanoparticles signify improved therapeutic outcomes and cost-effectiveness for stakeholders.
Tailored Solutions:
- With customizable drug loading and release profiles, the technology enables tailored solutions for specific medical and agricultural challenges, providing a competitive edge in the market.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Mukesh Doble,
Department. of Biotechnology
Prof. Sampath Kumar T S
Department. of Metallurgical & Materials Engineering
Intellectual Property
- IITM IDF Ref. 1722
- IN 370306 – Patent Granted
Technology Readiness Level
TRL – 3
Technology concept formulated.