Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Process for the Sustainable Production of Camptothecin
Technology Category/Market
Technology: Production of camptothecin.
Industry: Therapeutic Industry, Pharmaceutical;
Application: Cancer Chemotherapy, etc.
Market: The global Camptothecin market is projected to grow $12.54M by 2028 at a CAGR of 10.52% during the period (2023 -2028);
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Targeted Industries
Watermarking IP design,
Electronic circuits
Problem Statement
- Metabolites produced by plants are high significance owing to their therapeutic applications in humans.
- Endophytes, the microorganisms that reside within the tissues of plants are reported to have the ability to produce their host specific metabolites. And further, Camptothecin is one of such metabolites produced majorly from plants, which has demand for it’s anti-cancer activity.
- Plants producing camptothecin were exploited in large number to meet the demand.
- Therefore, to prevent such plants from getting extinct & to meet the demand for camptothecin, an alternate method of production is highly required. Hence, there is a need to address said issues efficiently.
Technology
- Present invention describes a process for sustainable production of camptothecin in suspension culture of endophyles from Nothapodytes nimmoniana.
- The endophytes are fungal strains consisting of A. burnsii (NCIM1409) or A. alstroemeriae (NCIM 1408).
- The proposed process involves the production of camptothecin, wherein A.burnsii produces 150-200µg/g DW biomass of camptothecin or 1.5-3mg/L titer of camptothecin in suspension, & A. alstroemeriae (NCIM 1408) produces 300-400µg/g DW biomass of camptothecin.
Key Features/Value Proposition
- Present invention describes a process for sustainable production of camptothecin in suspension culture of endophyles from Nothapodytes nimmoniana.
- The endophytes are fungal strains consisting of A. burnsii (NCIM1409) or A. alstroemeriae (NCIM 1408).
- The proposed process involves the production of camptothecin, wherein A.burnsii produces 150-200µg/g DW biomass of camptothecin or 1.5-3mg/L titer of camptothecin in suspension, & A. alstroemeriae (NCIM 1408) produces 300-400µg/g DW biomass of camptothecin.
Questions about this Technology?
Contact for Licensing
Research Lab
Prof. Smita Srivastava
Department of Biotechnology
Intellectual Property
- IITM IDF Ref.: 1761;
- Patent Application No. 201841032471
- PCT Application. No. PCT/IN2019/050626
Technology Readiness Level
TRL- 3
Proof of Concept Ready Stage