• The Conventional oral dosage forms (tablets and capsules) lack control over drug delivery, resulting in fluctuations in blood plasma drug concentrations, which can lead to drug resistance and toxicity.
• These conventional dosage forms cannot be used for stomach-specific sustained release due to their short residence time in the stomach and lack of drug delivery control.
• The need for prolonged and controlled drug release in the stomach necessitates a solution to increase Gastric Residence Time (GRT) while avoiding the use of non-biocompatible hydrophobic polymers and wasteful water/oil mediums in drug delivery systems.

The invention is a method for preparing biopolymer-based sustained-release floating beads for drug delivery using biomaterials. (Fig. 1A&B, 2)

Mixing Biopolymers:

Biopolymers, including collagen, chitosan, and collagen-peptide, are mixed together at a specific RPM using a stirrer to create a homogeneous solution.

Homogeneous Solution Processing:

The homogeneous solution is filtered and degassed in a cold environment to ensure uniformity.

Freezing:

The homogeneous solution is released through a syringe into liquid nitrogen for instantaneous freezing, resulting in the formation of frozen beads.

Lyophilization:

The frozen beads are then lyophilized to obtain biopolymer-based floating beads for drug delivery, which can be used for controlled drug release.