Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras

A Process for Fabrication of Pure/Macroporous Apatitic (CDHA) Bone Cement for Non-load Bearing Orthopedic Applications

Categories for this Invention

Biomaterials and Biomedical Engineering

Applications– Bone Grafting, Implant Fixations, Void Filling, Orthopedic Coating

Industry – Orthopedic Devices and Implants.

Market- Global orthopedic biomaterials market size was estimated at USD 19.2 billion in 2022 and is expected to grow at a CAGR of 7.8% from 2023 to 2030.

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Problem Statement

  • Addressing bone tissue defects and loss is a significant concern in orthopedics, requiring advanced regenerative procedures.
  • Highlighting the promising features of CPCs, such as higher biocompatibility, bioactivity, and bioresorbability, for bone grafting applications.
  • Exploring the potential of utilizing eggshell waste as a rich source of calcium for deriving calcium phosphate materials with trace elements mimicking human bone composition.
  • Further, Recognizing limitations in current bone cement technologies and proposing a novel process for fabricating calcium deficient hydroxyapatite (CDHA) bone cements with improved injectability, macroporosity, and resorbability properties for effective bone grafting applications.

Technology

Innovative Synthesis Methodology:

  • The process introduces a microwave-accelerated wet chemical synthesis for nano-crystalline hydroxyapatite, ensuring efficient and controlled production.

Eggshell-Derived β-TCP Synthesis:

  • Utilizing eggshell waste for synthesizing pure β-tricalcium phosphate (ESD β-TCP) adds sustainability and cost-effectiveness to the manufacturing process.

Tailored Cement Formulation:

  • The cement preparation involves a precisely formulated combination of synthetic and eggshell-derived components, providing versatility and adaptability for varied orthopedic applications.

Polymeric Liquid Phase Enhancement:

  • Incorporating disodium hydrogen phosphate, gelatin, and chitosan in the liquid phase enhances the mechanical and biological properties of the resulting bone cement.

Innovative Porogen Agent Integration:

  • The inclusion of mannitol or polysorbate as a porogen agent introduces a controlled porosity element, contributing to improved macroporosity in the final product.

Optimized CDHA Phase Formation:

  • The process ensures the formation of a pure apatitic (CDHA) phase in bone cement with defined dimensions, allowing for efficient bioresorption and enhanced biocompatibility.

Key Features / Value Proposition

Cost Efficiency and Affordability:

  • The chemical method significantly reduces costs compared to growth factor-based approaches, offering an economically viable solution for hepatocyte differentiation

Rapid Differentiation Timeline:

  • Achieves functional hepatocyte differentiation in just 14 days, providing a time-efficient alternative to the conventional 28-day duration associated with growth factor-based methods.

Consistent and Defined Media Composition:

  • The chemically defined media ensures consistency, eliminating batch-to-batch variation and providing a standardized protocol for deriving functional hepatocytes.

Clinical Viability and Safety:

  • Derives hepatocytes from mesenchymal stem cells, already used in clinical settings, ensuring safety and making it a suitable candidate for clinical applications in liver failure treatment.

Alternative to Growth Factors:

  • Overcomes the need for growth factors, reducing the overall complexity and cost of the differentiation process for functional hepatocytes.

Versatile Applications:

  • Extends beyond liver failure treatment to include potential applications in cell-based therapeutics and in vitro drug testing, enhancing its versatility and relevance across multiple domains.

Questions about this Technology?

Contact For Licensing

sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in

Research Lab

Prof. Sampath Kumar T S

Department of Metallurgical and Materials Engineering

Prof. Mukesh Doble

Department of Biotechnology

Intellectual Property

  • IITM IDF Ref. 2276
  • IN 410938 – Patent Granted

Technology Readiness Level

TRL – 4

Technology validated in lab scale.

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