Microfluidic Device and Method of Manufacturing thereof

Technology: Microfluidic Device.

Industry: Pharmaceutical, Medical device.

Applications: Medical Device.

Market: The global microfluidics market is projected to grow at a CAGR of 12.22% during 2024-2030.

In the present era, it is noted that there are significant challenges in the ultra-purification of blood associated with the device used in the diffusion process, being bulky, time-consuming, and involving high cost.
The present invention addresses the technical problem stating how to provide bio-compatible microfluidic devices for ultra-purification of blood that overcome the limitation of ionic imbalance and also a method of fabrication of the micro-features of the microfluidic devices using high-quality masters.
Hence, the present invention provides the solution to the above issues in an efficient manner.

The present invention describes a microfluidic device which operates on deterministic lateral displacement through micropillars which is used to separate blood cells from plasma.
Further present invention discloses about the fabrication of polymeric bio microfluidic devices for ultra purification of blood, i.e. application of femtosecond lasers for the fabrication of the masters.
The microfluidic device comprises at least one deterministic Lateral Displacement (DLD) assembly for filtering one or more constituents in the bloodstream.
The DLD assembly comprises micro-structures formed in micro-channels.
The bloodstream passing through the micro-structures is separated into a first bloodstream comprising blood plasma with potassium (K+) ions and a second bloodstream containing blood cells.
A diffusion assembly comprises a buffer inlet for intake of a buffer solution containing sodium (Na+) ions, a cellulose membrane receiving the buffer solution and the first bloodstream.

Technical Perspective:

Provides a low-cost & portable microfluidic device for ultra-purification of blood, and method of fabrication thereof.
Provides a method of fabrication of micro-features of the microfluidic device using high-quality masters.
Fabricate a microfluidic device for efficient ionic separation in fluids, such as blood, to maintain ionic balance in the bloodstream.

Industrial Perspective:

Fabricate cost-effective high throughout and bio-compatible microfluidic device for ultra-purification of blood and method of fabrication thereof.

Prof. Samuel G L

Department of Mechanical Engineering

TRL-3/4

Proof of Concept ready, tested in lab.

Technology Transfer