Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
System and Method for Monitoring Cardiac and Breath Rate of Rodents
Technology Category/Market
Category – Medical Devices
Applications – Bio-medical instrumentation, Bio-signal monitoring device, Small animal monitoring system.
Industry – Medical devices, Biomedical Research, Veterinary Medicine.
Market – The veterinary monitoring equipment market size accounted for USD 427.5 million in 2022 and is estimated to grow at 9.4% CAGR to reach USD 1 billion by 2032.
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Problem Statement
- Generally, the heart’s cardiac signals are picked up using non-invasive electrodes, minimally invasive electrodes, or telemetry (wireless) techniques.
- However, the ECG recording devices are expensive, and require a skilled or trained person to handle the device.
- In-vivo studies in animals, particularly in rodents, are usually performed widely in life science research.
- During such studies, it is vital to monitor the basic physiological parameters such as body temperature, heartbeat rate and breath rate of the animals.
Technology
- The present invention provides a system with a single sensing unit for estimating the breath rate and heartbeat rate of the animals, rodents in particular, from their cardiac signals/ECG signals in a non-invasive, cost-effective minimalistic manner. (refer Fig. 2)
- Said system facilitates acquiring, interpreting the cardiac signals in a non-invasive manner and serves the purpose of estimating the breath rate and the heartbeat rate of animals from the cardiac signals without the employment of separate means for said purpose.
- In other words, the system does not employ any respiratory sensor, to estimate the breath rate, rather it processes the cardiac signals and provides an accurate estimate of breath rate and heartbeat rate from said cardiac signals which it acquires from the animal in the interval of every 1-2 ms, sufficient to evaluate the accurate PQRS waveform of the cardiac signals.
- The present invention also provides a non-invasive, non-diagnostic method for estimating the breath rate and heartbeat rate of the animals, rodents in particular from their cardiac signals/ECG signals, which is highly affordable and easy to perform. (refer Fig. 3)
Key Features/Value Proposition
Retrospective Cardiopulmonary Imaging:
- The system detects, analyzes, and processes cardiac signals (ECG) to enable retrospective gating for cardiopulmonary imaging, reducing radiation exposure.
Integration with High Frame Rate Detector:
- The system could be integrated with a sensitive high frame rate detector and employed for retrospective cardiac gating, which generates high-resolution cardiac images with less radiation exposure.
Cost Efficiency:
- The cost of the system is at least 70% less than the existing solutions.
Direct Monitoring and Estimation:
- Offers an effective direct method for monitoring and estimating the cardiac or breath rate of anesthetized rodents without the need for separate respiratory sensors.
Heartbeat Rate Estimation:
- The heartbeat rate is estimated from consecutive R-peak waves and derived from the PQRS waveform, which also helps in prospective cardiac gating studies.
Simplified Vital Sign Monitoring:
- It provides a simple derivation method to estimate the heart and breath rate, which is helpful for monitoring physiological vitals and in in-vivo pharmacological studies.
Questions about this Technology?
Contact for Licensing
Research Lab
Prof. Ganapathy Krishnamurthi
Department of Engineering Design
Intellectual Property
- IITM IDF Ref. 2327
- IN 202241015433
Technology Readiness Level
TRL- 4
Technology validated in lab.