Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
A Scaffold of Nanofibrous Matrix as a Diabetic Wound Dressing
Categories for this Invention
Technology: Scaffold of nanofibrous matrix;
Industry & Application Biotechnology & pharmaceutical companies; Biomedical Device;
Market: The global scaffold technology market is projected to grow USD 5.09Bn by 2031, at a CAGR of 18% during the forecast period (2024-31)
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Problem Statement
- In the present subject matter, the problem in electrospinning agarosecurdlan blend is that agarose & curdlan are soluble in hot aqueous solution at higher temperature, however they gel/solidify at room temperature and hence such a blend could not be employed for the production of nanofibers by means of electrospinning.
- The present invention addresses said problem and provides a means for the production of scaffold.
Technology
- Present patent is related to a scaffold comprising a matrix of nanofibers, which is meant for healing chronic wounds and is prepared from a blend of biocompatible polymers using an electrospinning technique.
- Further, said patent explains a method for producing a scaffold for chronic wound healing.
- Present Patent comprises a matrix of nanofibers of biocompatible polymers comprising agarose, curdlan, polyvinyl alcohol with or without antibacterial drug.
- Said nanofibers are a blend of biocompatible polymers comprising
- 1%-10% w/v of agarose in formic acid or DMSO;
- 1%-5% w/v of curdlan in formic acid or DMSO; and
- 10%-12% w/v of polyvinyl alcohol in water,
- wherein the ratio of combination of agarose in formic acid or DMSO and curdlan in formic acid or DMSO to polyvinyl alcohol in water in the blend ranges from 1:2 to 1:4.
Key Features / Value Proposition
Technical Perspective:
Important Features:
- The nanofibers of biocompatible polymers further comprise antibacterial drug, and it helps combat infection and hasten the healing cascade.
- Said scaffold effectively absorbs the exude emanating from chronic wounds such as fungating wounds, fistulae, venous leg ulcers, and diabetic foot ulcers, and poses no exude leakage problem, & specifically advantageous for healing said chronic wounds.
- The scaffold facilitates easy transmission into space-restricted wounds (cavity wounds) with greater flexibility.
- The matrix of nonwoven nanofibers have diameter in the range of 115-146 nm with effective exude absorption ability (~ 450 – 500 % swelling).
- Exemplary: Cell viability was ~90% using mouse fibroblasts (L929 cell line) i.e. better cell viability (Refer Fig 4a)
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Sampath Kumar T S
Department of Metallurgical and Materials Engg.
Prof. Mukesh Doble
Department of Biotechnology
Intellectual Property
IITM IDF Ref. 2427
IN Patent No. 523793 (Granted)
Technology Readiness Level
TRL-3
Experimental proof of concept;