Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Process for preparation of stable, colloidal suspension of micronized water insoluble ß-glucan and its application thereof.
Categories for this Invention
Category: Micro & Nano Technologies
Industries: Nutraceuticals, Aquaculture, Pharmaceutical, Food and Beverage, Cosmetics
Applications: Immune stimulation, Drug delivery, Animal feed supplements, Health supplements, Disease prevention in aquaculture, Cosmetic formulations
Market: The global ß-glucan market size is estimated to grow from USD 501 Mn in 2023 to USD 734 Mn by 2028, representing 7.9% CAGR during the forecasted period 2023-2028.
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Problem Statement
- Current methods for preparing water-insoluble β-glucan lacks efficiency and scalability and are very time-consuming.
- Traditional method for aggregation of β-glucan particles reduces solubility & effectiveness in immune stimulation.
- Existing approaches for micronization involves chemical modification.
- Hence, there is a need for a method to produce stable, colloidal suspensions of micronized β-glucan for enhanced immune-stimulant activity.
Technology
The instant technology disclosure refers to a novel approach for preparation of stable colloidal suspensions of micronized water-insoluble β-glucan, with diverse applications.
The disclosure involves a two-step process:
- Dried yeast is dispersed in distilled water, centrifuged, treated with NaOH and HCl, boiled and washed until pH neutralization, resulting in a carbohydrate-rich fraction containing β-glucan.
- The β-glucan particles are micronized by homogenizing larger particles under selective pressures, achieving a concentration of 50-100mg/ml on a dry basis. This enhances absorption in the intestine and improves binding with macrophages, enhancing immune-stimulant activity.
Key Features / Value Proposition
- Cost-effective & scalable method for large-scale production.
- Retention of natural β-glucan properties without altering its structure.
- Sustainable two-step extraction process from brewer’s yeast.
- Formation of micronized water-insoluble β-glucan particles without chemical modification.
- Homogenization under selective pressures to achieve nanometer-sized particles.
- Stable colloidal suspension with enhanced immune-stimulant activity.
- Improved absorption and binding with macrophages for potent immune stimulation.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Chandra T S
Department of Biotechnology
Intellectual Property
IITM IDF No: 1890
IN IP No: 401089 (Granted)
Technology Readiness Level
TRL – 4
Experimentally validated in lab.