Automated Coverslipper for Large Format Slides with Switchable Compatibility to Handle Multi Format Slides
Categories for this Invention
Technology: Automated coverslipper to handle multi format slides
Category: Biotechnology & Genetic Engineering
Industry: Biomedical
Application: Tissue engineering
Market: The global market size was valued at USD 184.5 Million in 2023 and is projected to reach USD 259.2 Million by 2030, growing at a CAGR of 5.1% during the forecast period 2024-2030.
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Problem Statement
- Periodontitis is an inflammation caused by biofilms, causing tooth loss and edentulism.
- Traditional treatments involve guided tissue regeneration using periodontal membranes.
- Graphene, with its large surface area, high thermal and electrical conductivity, and superior mechanical properties, has been used in engineering and biomedical fields.
- Recent developments in 3D graphene foams (GFs) have been developed to avoid agglomeration and facilitate uniform distributions, making them ideal for scaffold preparation in tissue engineering and regenerative medicine.
- However, there is a gap in understanding 3-D organization in multicellular tissue formation and functional restoration on scaffolds.
Technology
- A coverslipping system consists of a coverslipper device on a frame that moves from one or more zones.
- A coverslipping system consists of a coverslipper device on a frame that moves from one or more zones.
- The dispensation zone dispenses a mountant medium, and the slip pick-up zone picks up the coverslips from the tray.
- The coverslipping zone positions the platform in the coverslipping zone, and the picked coverslip is mounted over the slide.
- The output zone transports the processed cover slip slide and inserts it into a tray, which is moved up and down to accommodate the next processed slide.
Key Features / Value Proposition
Coverslipper Device Overview:
- Processes large format slides of 6” X 8” and 5” X 7”, and can be customized to smaller sizes.
- Features a slide tray with stained slides inserted into grooves for easy pick-up. Uses a wedge-shaped nozzle to uniformly dispense mountant medium over the slide.
- Controlled by a dedicated algorithm for accurate and uniform placement and air bubble prevention.
- Composed of a vertical plate, a first curved plate, and a second curved plate.
- Rotates the second curved plate along a predefined path, allowing vacuum suction cups to lift the cover slip.
- Achieves a unique locus of motion to prevent air pockets and bubbles below the cover slip.The rack mimics human ankle motion between Dorsiflexion and Plantarflexion positions.
Uses and Applications:
- Prevents contact between the microscope’s objective lens and the specimen.
- Provides an even thickness (in wet mounts) for viewing depth.
- Viewing enhancement as the specimen is flattened.
- Deceleration of evaporation from the sample, both in wet and dry mounted slides.
- Permanent affixation for long term and repeated use of Permanent Specimens.
Large Format Specimen Protection and Storage:
- Enables long-term preservation and storage of large format specimens.
- Economizes cover-slipping process through indigenous algorithms
- Versatile, supporting multiple slide sizes, a unique feature not found anywhere else
- Supports cover-slipping of large quantities of slides, like adult human brain sections.
- Processes large format cover-slips, a unique feature not developed globally.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Jayaraj Joseph
Prof. Mohanasankar sivaprakasam
Department of Electrical Engineering
Intellectual Property
IITM IDF Ref. 2202
Patent No: IN 546396
PCT/IN2022/050598
Technology Readiness Level
TRL- 4
Experimentally validated in Lab
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