Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
3D Printed Three-layered Polymer Scaffold for Periodontal Regeneration, Method for Preparing the Scaffold
Technology Category/Market
Technology: 3d Printed Three-layered polymer scaffold for periodontal regeneration, method for preparing the scaffold
Category: Biotechnology & Genetic Engineering
Industry: Biomedical
Application: Osteochondral tissue engineering to facilitate multi tissue regenerations.
Market: The global market size is USD 1.55 trillion in 2023 and is projected to grow at a CAGR of 13.96% from 2024 to 2030.
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Problem Statement
- Periodontitis is a prevalent non-communicable disease affecting teeth, cementum, bone, and periodontal ligament.
- Current treatments include plaque elimination, controlling inflammation, and periodontal surgeries.
- Regeneration of periodontal structure requires quality regeneration of all three tissues, in the right quantity, and in the same architecture as native tissue.
- 3D printing technology has gained popularity in dentistry for creating multi-layered scaffolds, but it does not fully mimic the native periodontal complex and does not guide fiber orientation or anchoring.
- Various designs have been proposed for regeneration.
Technology
3D Printed Three-Layer Polymer Scaffold
- First scaffold: Vertical polymer scaffold containing angular tubes.
- Second scaffold: Continuous slots to glide over other end of angular tubes.
- Angular tubes have wide pores for fibroblast migration.
- Both scaffolds contain polymers from polylactic acid (PLA) and polyethylene terephthalate glycol (PET-G).
- Printing first and second scaffolds to a platform temperature of 550C to 700C.
Key Features/Value Proposition
Layer arrangement:
- First, Second, Third layers.
First scaffold:
- Vertical scaffold with angular tubes.
- Vertical scaffold: 6mm x 6mmx 0.3mm to 12mmx 12mmx0.6mm.
- Polymer weight: First scaffold: 255mg to 265mg;
Second scaffold:
- Continuous slots to glide over the first scaffold’s angular tubes.
- Polymer weight: Second scaffold: 75mg to 85mg.
- Second scaffold: 6.5mm x 6mmx 0.3mm to 13mmx 12mmx0.6mm.
Angular tubes:
- Wide pores for fibroblast migration and population.
- Pore diameters ranging from 0.1mm to 0.2mm.
- Equal spacing of angular tubes on vertical scaffold.
- Angles: 55°-70°, 90°, 100°-120°
- Angled tubes: 2mm to 4mm, outer diameter 1mm to 2mm, inner diameter 0.8 mm to 1.6mm.
Coating:
- Collagen, poly-L-lysine, hydrogel gelatin methacryloyl (GelMA), and fibronectin.
3D Printing Method:
- Step (a) printed using a 3D printer at nozzle temperature between 1950°C and 2400°C.
- Step includes coating scaffold with components from collagen, poly-L-lysine, hydrogel gelatin methacryloyl (GelMA), and fibronectin.
Technique used:
- Fused deposition modeling (FDM).
Coating Scaffold with Components:
- Collagen, poly-L-lysine, Hydrogel Gelatin Methacryloyl (GelMA), and fibronectin.
Questions about this Technology?
Contact for Licensing
Research Lab
Prof. Tuhin Subhra Santra
Department of Engineering Design
Intellectual Property
IITM IDF Ref. 2394
Patent No: IN 552910
Technology Readiness Level
TRL- 3
Experimental proof of concept