Method for using Bulk and Porous N-containing/N-doped Carbon and Carbon Nitrides as Heterogeneous Catalysts for Borrowing Hydrogen and Dehydrogenation Reactions
Technology Category/ Market
Categories: Chemistry & Chemical Analysis, Medical & Surgical Devices
Application: long segmental bone  repairing, reconstruction of bones, bone flexibility
Market: Heterogeneous Catalyst Market size was valued at $ 40 B in 2021 and is poised to grow from $ 41.76 B in 2022 to $ 56.45 B by 2030, growing at a CAGR of 4.4% in years 2023-2030.
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Problem Statement
- Repairing of the long segmental bone defects is challenging in orthopedic practice.
- Limitations related with bone grafts use: tissue availability, increased surgery time, donor site morbidity, high cost, uncertain bone healing, disease transmission risk & undesirable host immune response.
- Most load-bearing metal orthopedic implants are made of titanium/stainless steel due to their mechanical strength, inertness or Osseo integration (titanium). Limitation of stress shielding with release of toxic metallic ions that enhance inflammatory response, inability to adapt human body growth & poor bioactivity, takes long healing time or infection second surgery to remove implant after recovery.
- To overcome these issues, the present patent is disclosed which relates magnesium-based biodegradable metallic material, implant device for medical application.
Technology
A method of preparation of a catalyst of N-containing/N-doped carbons and carbon nitrides said method comprising:
- Preparing at least one N-containing/N-doped carbon materials with nitrogen containing carbon precursors;
- Pyrolyzing the resulting carbon nitrogen-containing/-doped carbon and carbon nitrides – in the temperature range of 500-1000°C
- Centrifuging and washing the material with ethanol; drying to obtain the N-containing /N-doped porous carbons and carbon nitrides.
- wherein N-containing/N-doped carbons/carbon nitrides additionally is methylated by suspending N-doped mesoporous carbon in methyl iodide (CH3I) reagent under stirring at 40- 100°C (for 1-12 h) & centrifuging and washing the material with ethanol; drying to get the N- methylated N-containing/N-doped carbons/carbon nitrides.
- The method of catalyzing one of the organic transformations such as N-alkylation of amines; C-alkylation of ketones; and synthesis of quinolines said method comprising steps of: reacting the mesoporous N-containing/N-doped carbons and carbon nitrides catalyst prepared with respective amines or ketones or quinolines with the alkylating reagent in a tube reactor charged with inert gas in atmospheric pressure at temperatures 80- 140 °C for period of 1-24 h, wherein the catalyst is 5-50 wt% with respective amines, ketones and quinolines in the presence 0.01 – 0.5 equivalent of a base; carrying out the reaction by stirring magnetically in hot oil bath.
Key Features / Value Proposition
- Provides flexibility to the reconstructed bone.
- Avoids stress shielding.
- Avoids second surgery-Removes implant after healing.
- Ability to accommodate various bioactive molecules/ antimicrobial agents & its controlled delivery.
- Improved bioactivity/biocompatibility.
- Biomimetic–mimics extracellular matrix (ECM) coating.
- Avoids infections – implant associated infections.
- Controlled corrosion, degradation via long term stability.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Selvam P
NCCR & Department of Chemistry
Intellectual Property
- IITM IDF Number: 1674
- IP Patent Number: 429993 (Granted)
- PCT/IN2019/050532
Technology Readiness Level
TRL – 4
Technology validation in Lab