Drug Loaded Plasmonic Core-shell Electrospun Nanofibres for Laser Mediated Intracellular Delivery

Technology: Nanofibres;

Industry: Pharmaceutical; Applications: Pharmaceutical & Drugs, Bio-medical Engineering;

Market: The global nanofibers market is projected to grow at a CAGR of 24% during 2021 to 2025;

Generally, it is noted that control over cell behaviors & cellular fates helps in various biomedical fields such as treating cancers, cell-based therapies, and tissue engineering.
Electrospun nanofibre has been proven & in order to increase the functionality of the nanofiber scaffolds, core-shell nanofibres are being developed.
Core-shell nanofibres constitute a biphasic scaffold with distinct inner core and the outer shell. The variation in core & shell chemical, & physical properties provides higher degree of functionalization to target drug/gene/biomolecule delivery.
Further a few patent literature has discussed, however unable to provide solution as discussed in the present invention.

The present invention describes a core-shell nanofiber. Said core-shell nanofiber comprising: an inner core, & an outer shell.
Said inner core comprises hydrophilic polymer and an active ingredient.
Further, the outer shell comprises a hydrophobic polymer and plasmonic nanoparticles.
Moreover, present invention describes a method of preparing a core-shell nanofibre, & a method to deliver the active ingredient to cells on-demand by laser mediated drug delivery technique.
Discussed a method for preparing core-shell nanofibres composed of hydrophilic core with an active substance (drug) reinforcement and hydrophobic shell with plasmonic nanoparticles, by dual syringe system based electrospinning.(Refer Figure)
Subject matter includes the fabrication of core shell electrospun nanofibers composed of hydrophilic polyvinyl alcohol (PVA) core with curcumin drug reinforcement & hydrophobic polycaprolactone(PCL) shell with gold nanoparticles.
The core-shell electrospun nanofibres mediated laser based optoporation for drug delivery has performed on the neurons cell shown in figure.1

Technical Perspective:

Claimed invention provides a method to deliver the active ingredient to the site of action without destruction of cells.
The development of core-shell nanofibre based laser assisted drug delivery process is shown in the flowchart.

Industrial Perspective:

The plasmonic nanoparticles are gold nanostar nanoparticles.
the average diameter of core-shell structure of the nanofibers was found to be approximately 300 nm based on Fig. 2a,2b.

Prof. Tuhin Subhra Santra

Department of Engineering Design

TRL- 4

Proof of Concept ready, validated

Technology Transfer