Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
Metal-Free approach and Method for Synthesis of Polyesters
Categories for this Invention
Technology: Metal free synthesis of polyester
Category: Chemistry & Chemical Analysis
Industry: Polymer
Application: Biomedical
Market: The global market size was reached USD 716.83 billion in 2022 and is expected to reach around USD 1,207.11 billion by the end of 2032, growing at a compound annual growth rate (CAGR) of 5.4% from 2023 to 2032
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Problem Statement
- The conventional methods for synthesizing semi-aromatic polyesters use a Ring Opening Copolymerization (ROCOP) reaction with monomers and organometallic catalysts.
- This method is unsafe and can lead to environmental and human health issues.
- Metal catalysts are prone to transformations, such as hydrolysis and alkylation, and can cause chemical changes when in contact with body fluids.
- Prior methods do not adapt metal-free catalysts, and the synthesis of organometallic catalysts is not cost-effective.
- Therefore, an improved metal-free approach is needed for the synthesis of poly(tBGE-alt-PA) copolymers.
Technology
- Synthesis of poly(tbge (tert-butyl glycidyl ether)-alt-pa (phthalic anhydride)) copolymer
- ring-opening copolymerisation (rocop) reaction
- pa (phthalic anhydride) and tbge (tert-butyl glycidyl ethere) as comonomers
- ppncl (bis(triphenylphosphoranylidene)
ammonium chloride) and triethyl borane as metal-free catalysts.
Key Features / Value Proposition
Reaction vessel:
- Dry schlenk tube under argon atmosphere.
Monomers:
- PA, tBGE, Et3B, PPNCl, immersed in oil bath at 100°C.
Reaction
- Acetic acid solution quenched polymerization reaction.
- Precipitated copolymer dissolved in dichloromethane, precipitated with cold methanol.
- Dialysis with distilled water removed low molecular weight copolymer and unreacted monomer.
Yield
- Poly(tBGE-alt-PA) copolymer synthesized via ROCOP reaction with over 99% yield.
Advantages
- Metal-Free Polyester Synthesis
- Eco-friendly and biocompatible.
Application
- Widely used in biomedical applications like drug delivery and tissue engineering.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Rama S Verma – Department of BiotechnologyÂ
Prof. Debashis Chakraborty – Department of Chemistry
Intellectual Property
IITM IDF Ref. 1682
Patent No: IN 351891
Technology Readiness Level
TRL- 4
Experimentally validated in Lab