Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
High-Sensitivity Molecularly Imprinted Polymer Based Glucose Sensor
Categories for this Invention
Technology: MIP Based Glucose Sensor;
Industry & Application: Bio medical Engineering, Medical Device, Bio-Electronics;
Market: The global glucose sensor market is projected to grow at a CAGR of 8.6% during 2024-2032.
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Problem Statement
- Present need is to develop a glucose diagnostic tool which is pain free, non-invasive, user-friendly, reliable & accurate monitoring of glucose levels. There are various biological fluids other than blood is being explored such as sweat, tears, saliva, urine, & tissue/interstitial fluids.
- To detect glucose in the human sweat requires a powerful sensing technique. As sweat is a complex physiological mixture, the selectivity detection of glucose is a difficult task, due to major drawbacks includes costlier procedures, shelf life & cumbersome immobilization procedures. Hence, there is a need to address the issues.
Technology
- The present invention describes a molecular imprinted polymer biosensor device for sensitive detection of glucose from sweat present on skin.
- Said biosensor device comprising a paper substrate, a working electrode, a counter electrode and a reference electrode of carbon formed on the paper substrate, a molecular imprinted polypyrrole polymer sensing portion coated onto the working electrode.
- Herein the polypyrrole is imprinted for detection of glucose.
- Further, the device is configured for measurement of glucose concentration using electrochemical impedance spectroscopy (EIS).
- Further, the present invention is directed to a method for preparing polypyrrole molecular imprinted polymer (MIP) sensor for glucose detection.
- In this instance, the method discloses a few steps including the coating of the sensing portion.
- Coating the sensing portion includes dispersing 1mg of synthesized molecular imprinted polymer (MIP) in 1mL water and coating the sensing portion of the working electrode, followed by drying at 60⁰C for 30 minutes.
Key Features / Value Proposition
Technical Perspective:
- The device is configured to have
- a linear detection range between 3nM to 1.8mM,
- Sensitivity of 2.41KΩ∕µm-1/mm-2 or higher or a detection limit of 4.8nM or lower.
- The sensor is stable when stored under indoor storage conditions for 80 days or more.
- Further present invention discussed about the method for preparing polypyrrole molecular imprinted polymer (MIP) sensor for glucose detection.
- The method for obtaining the MIP in pellet form comprises repeatedly washing and centrifuging the pellet 3 or more times to remove the template molecule, followed by drying the washed pellet in a hot air oven at 120⁰C for 12 hours.
Industrial Perspective:
- The claimed device is advantages such as high selectivity, high sensitivity, high signal to noise ratio, & rapid response time.
- Provides cost-effective compact device.
- Facilitates Pain free, non-invasive, user friendly, reliable & accurate glucose detecting device.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Pallab Sinha Mahapatra
Department of Mechanical Engineering
Prof. Tuhin Subhra Santra
Department of Engineering Design
Intellectual Property
IITM IDF Ref. 2534
IN Patent No:473848
Technology Readiness Level
TRL-4
Proof of Concept ready, tested in lab.