Microgravity-based Drug Loading Method

• Utilizes microgravity conditions, typically achieved using equipment like RPM, Clinostat, or Rotating Wall Vessel.
• Reduces gravitational force to 10^-3 to 10^-4 times standard gravity, minimizing particle agglomeration.
• Enhances mixing and distribution of drugs within nanomaterials, improving loading efficiency.
• Optimizes drug-nanomaterial interaction, potentially leading to higher drug encapsulation or adsorption onto nanocarriers.

Nanomaterials and Drug Types

• Applicable to various nanomaterials like IONP, liposomes, polymer nanoparticles, and MOFs.
• Drug types loaded include anticancer drugs(eg. Cisplatin), proteins, peptides, nucleic acids, vitamins, and other therapeutic agents.
• Supports loading multiple drug types onto the same nanomaterial platform.

Process and Efficiency

• The drug and nanomaterial mixture undergoes microgravity exposure for 6-18 hours, improving efficiency by 2-4 times compared to standard gravity or shaking.
• The nanomaterials maintain therapeutic effects and exhibit similar drug release profiles.

Characterization and Evaluation

• The technology utilizes common characterization techniques like UV-Vis spectrophotometry, SEM (Scanning Electron Microscopy), XRD (X-ray Diffraction), and FTIR (Fourier Transform Infrared Spectroscopy) to confirm the quality, size, morphology, and loading efficiency of the nanomaterials.