Industrial Consultancy & Sponsored Research (IC&SR) , IIT Madras
A Bioreactor for Tissue Engineering
Categories for this Invention
Category – Advanced Biomanufacturing
Applications – Tissue Engineering, Cell-Based Therapies, Biomaterials Fabrication
Industry – Biotechnology and Pharmaceutical
Market – Bioreactor Market, valued at USD 5.31 billion in 2024, is projected to reach USD 7.60 billion by 2029, growing at a CAGR of 7.45%
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Problem Statement
- Traditional bioreactors require intricate designs or sensors to effectively detect and optimize cell and tissue culture.
- There is a demand for bioreactors that can achieve tissue growth with fewer complexities, particularly through the application of physiological flows and stresses.
- Existing bioreactors lack the capability to provide optimal environments for diverse tissue, organ, or cell production with the required functionality.
Technology
- Controlled Environment for Cell Growth: The bioreactor is designed with at least two chambers, equipped with sensors and a controller to monitor and regulate conditions like temperature, pH, and gas concentration, enhancing cell proliferation and differentiation with or without scaffolds.
- Electromechanical Drive Mechanism: The bioreactor features an electromechanical system that applies magnetic fields and shear stress to the cells, promoting cell growth and maturation, with adjustable inlet/outlet ports for precise environmental control.
- Advanced Monitoring and Agitation: The system includes a conical platform and membrane filters to manage cell transfer between chambers, while integrated sensors provide feedback to maintain optimal conditions, ensuring high-quality tissue or cell culture production.
Key Features / Value Proposition
1. Enhanced Cell Growth:
- Optimized for both scaffold-based and scaffold-free cell culture, boosting cell proliferation and differentiation rates.
2. Precision Environmental Control:
- Integrated sensors and controllers regulate critical factors like temperature, pH, and gas levels, ensuring consistent and reproducible cell culture conditions.
3. Shear Stress and Magnetic Field Application
- Electromechanical drive mechanism imparts controlled shear stress and magnetic fields, enhancing cellular responses and tissue maturation.
4. Scalable Dual-Chamber Design:
- Modular bioreactor with separated chambers allows for distinct stages of cell culture, from initial growth to final maturation.
5. Real-Time Monitoring:
- Advanced sensors, including temperature, osmolality, and pH, provide continuous feedback, enabling precise adjustments to the cell culture environment.
6. Customizable and Versatile:
- Adaptable configuration with replaceable components like membranes and heat exchangers, suitable for various cell types and research applications.
Questions about this Technology?
Contact For Licensing
sm-marketing@imail.iitm.ac.in
ipoffice2@iitm.ac.in
Research Lab
Prof. Venkatesh Balasubramanian
Prof. Soma Guhathakurta
Department of Engineering Design
Intellectual Property
- IITM IDF Ref. 976
- IN 510399 – Patent Granted
Technology Readiness Level
TRL – 5
Technology validated in relevant environment.